ld50 of euphorbia hirta extract

  • PDF Phytochemical screening of Euphorbia hirta linn leaf

    The Ethanolic Extract of Euphorbia hirta Linn showed positive test for flavonoids saponins glycosides tannins phenolics steroids proteins and carbohydrate The various doses of ethanolic extract of Euphorbia hirta Linn were shows no mortality in mice No toxic symptoms were observed even at the dose of 5000 mg kg The LD 50 value of

  • Pharmacological Potential of Asthma Weed Euphorbia hirta

    in these extracts of Euphorbia hirta have revealed that the ethanolic extract contained the maximum phenolic content in terms of gallic acid equivalents than aqueous extract The total flavonoid content in aqueous and ethanol extracts were calculated as 27 37±0 39 QE mg g and 41 32±1 69 QE mg g The flavonoid contents of ethanol

  • Antioxidant activity and phytochemical screening of the

    Assessment of Euphorbia hirta L Leaf Flower Stem and Root Extracts for Their Antibacterial and Antifungal Activity and Brine Shrimp Lethality Mohammad Abu Basma Rajeh 1 Zakaria Zuraini 1 Sreenivasan Sasidharan 2 Lachimanan Yoga Latha 2 and Santhanam Amutha 2 3

  • Toxicity Effects of Methanolic Extract of Euphorbia hirta

    Euphorbia hirta aqueous extract Biomed J Vol 38 No 4 July - August 2015 drugs NSAIDs which act by inhibiting the COX enzyme are considered to be effective in the management of OA but are associated with safety efficacy and tolerability issues

  • Gatas-gatas Botobotones Asthma weed Euphorbia hirta

    Dec 10 2013· Despite Euphorbia hirta L ethnomedicinal benefits very few studies have described the potential toxicity The aim of the present study was to evaluate the in vivo toxicity of methanolic extracts of E hirta The acute and subchronic oral toxicity of E hirta was evaluated in Sprague Dawley rats The extract at a single dose of 5000 mg kg did not produce treatment related signs of toxicity or

  • Gatas-gatas Botobotones Asthma weed Euphorbia hirta

    Oral acute toxicity of the extract showed no mortality in Sprague Dawley rats at concentration of 50 300 2000 and 5000 mg kg body weight Result showed that the LD50 was 5000 mg kg The MBC MIC ration 4 suggesting the crude extract was bactericidal This study showed that leaves of E hirta can serve as a potential antibacterial agent

  • Antidiabetic and Free Radicals Scavenging Potential of

    The present study was carried out to evaluate antidiabetic and in vitro free radicals scavenging effects of flower extract of Euphorbia hirta The ethanolic and petroleum ether extracts 250 and 500 mg kg were orally tested for 21 days in alloxan induced diabetic mice …

  • Toxicity Studies on the Methanolic Extract of Portulaca

    Gatas-gatas tawa-tawa Euphorbia hirta Study evaluated the in vivo toxicity of methanolic extracts of E hirta in Sprague Dawley rats The LD 50 was estimated to be more than 5 000 mg kg Results showed long-term oral administration of E hirta extract for 90 days does not cause sub-chronic toxicity juice and extract of Euphorbia

  • Acute and Subchronic Toxicity Study of Euphorbia hirta L

    Acute toxicity impacts of Euphorbia hirta L extract on behavior organs body weight index and histopathology of organs of the mice and Artemia salina Mohammad Abu Basma Rajeh 1 Yuet Ping Kwan 2 Zuraini Zakaria 1 Lachimanan Yoga Latha 2 Subramanion L Jothy 2 Sreenivasan Sasidharan 2

  • Antidiabetic activity of ethanolic extract of Euphorbia

    The present invention relates to the use of Euphorbia Hirta L for the preparation of pharmaceutical compositions for the treatment of functional disorders and somatic manifestations related to anxiety Novel use of Euphorbia hirta L in therapy - Google Patents Novel use of Euphorbia hirta L in therapy 239000006286 aqueous extract

  • The Effect of Selected Sterilization Methods on

    Singh S K et al 2005 Toxic effect of stem bark and leaf of Euphorbia hirta plant against freshwater vector snail Lymnaea acuminata Chemosphere 59 2 263-70 Adedapo A A et al 2005 Anthelmintic efficacy of the aqueous crude extract of Euphorbia hirta Linn in Nigerian dogs Veterinarski Arhiv 75 1 39-47

  • Phytochemical screening and antimicrobial activity of

    N nigricollis venom was administered intraperitoneally at a dose of 1414µg kg body weight of mice and Euphorbia hirta extract was orally administered at a dose of 250mg kg body weight at different time interval in the in vivo assay The result for the LD50 of the plant extract showed no mortality

  • Antithrombotic and anti-inflammatory activities of leaf

    Euphorbia hirta sometimes called asthma-plant is a pantropical weed possibly native to India It is a hairy herb that grows in open grasslands roadsides and pathways It …

  • What Are the Medical Uses of Euphorbia Hirta with pictures

    Sterilization methods After carrying out antibacterial activity test of five different herbal plants extracts Euphorbia hirta extract was selected to study the effect of the sterilization methods Two sterilization methods were applied autoclaving of impregnated discs and filtration of the extracts

  • Acute toxicity impacts of Euphorbia hirta L extract on

    Twenty-four hour acute toxicity LD 50 result of the ethanolic leaf extract of Euphorbia hirta The different groups for the LD 50 of plant extract were given the different doses ml of extract above and the result presented in Table 1 Table 1 Result for the LD 50 experiment for plant extract Dose mg kg No of death Behavior

  • Antioxidant activity and phytochemical screening of the

    Journal of American Science 3 3 2007 C C Ogueke J N Ogbulie I C Okoli B N Anyanwu Antibacterial Activities And Toxicological Potentials Of Crude Ethanolic Extracts OF Euphorbia hirta concentrations of crude ethanolic extract of Euphorbia hirta

  • Euphorbia Hirta Herb Uses Benefits Cures Side Effects

    Acute and Subchronic Toxicity Study of Euphorbia hirta L Methanol Extract in Rats Article PDF Available in BioMed Research International 2013 2 182064 · December 2013 with 546 Reads

  • SCREENING OF EUPHORBIA HIRTA EXTRACTS FOR …

    Jan 12 2018· Toxicity Effects of Methanolic Extract of Euphorbia hirta-Honey Mixture in Albino Rats Ifeanyi Peter Onyeka 1 Mohammed M Suleiman 2 and Sunday P Bako 3 1 Department of Biological Sciences Faculty of Science Acute toxicity studies showed that LD 50 was greater than 5000 mg kg

  • FR2639229A1 - Novel use of Euphorbia hirta L in therapy

    Despite Euphorbia hirta L ethnomedicinal benefits very few studies have described the potential toxicity The aim of the present study was to evaluate the in vivo toxicity of methanolic extracts of E hirta The acute and subchronic oral toxicity of E hirta was evaluated in Sprague Dawley rats The extract at a single dose of 5000 x2009 mg kg did not produce treatment related signs of

  • Extracts of Euphorbia hirta Linn Euphorbiaceae and

    Euphorbia hirta commonly known as Tawa-Tawa is a plant used in folklore medicine in the Philippines for the treatment of dengue Though E hirta has been extensively investigated for numerous bioactivities limited studies have been conducted on the antidengue activity Thus the present study provides a comprehensive review of studies conducted on the antidengue activity of i E hirta i

  • Antidiabetic activity of ethanolic extract of Euphorbia

    Antioxidant activity and phytochemical screening of the methanol extracts of Euphorbia hirta L steroids tannins flavanoids and phenolic may relate the antioxidant activities of E hirta extract to the presence of these phytochemicals and thus the plant could serve as potential source in herbal medicine drugs In the present study the

  • What Are the Medical Uses of Euphorbia Hirta with pictures

    The in-vitro clot lysis test was performed to investigate the antithrombotic activity of Euphorbia hirta leaf methanolic extract In addition xylene-induced ear edema and cotton pellet-induced granuloma formation tests were conducted to evaluate the anti-inflammatory effect of methanolic extract of Euphorbia hirta leaves in mice

  • Acute and Subchronic Toxicity Study of Euphorbia hirta L

    Gatas-gatas tawa-tawa Euphorbia hirta Study evaluated the in vivo toxicity of methanolic extracts of E hirta in Sprague Dawley rats The LD 50 was estimated to be more than 5 000 mg kg Results showed long-term oral administration of E hirta extract for 90 days does not cause sub-chronic toxicity juice and extract of Euphorbia

  • ANTIBACTERIAL ACTIVITIES AND TOXICOLOGICAL …

    Ayurvedic medical practitioners in India use euphorbia hirta to treat bronchial conditions An extract of this medicinal plant can ease the symptoms of colds asthma bronchitis and coughs It is also used to treat urinary tract infections and venereal diseases such as syphilis and gonorrhea This healing herb is used to treat sexual disorders in males

  • Assessment of Euphorbia hirta L Leaf Flower Stem and

    Mar 18 2013· Among the 6 25 μg ml concentrations of E hirta immobilisation of mff occurred only in the ethyl acetate extract at 4 hours and also occurred in the chloroform extract at 6 hrs and aqueous extracts at 12 hrs At 4 hrs the least concentration of each of the E hirta extract that reduced motile mff numbers to less than 50 was 50 μg ml of the ethyl acetate extract 200 μg ml of the crude

  • Euphorbia hirta - Wikipedia

    Apr 07 2018· An ornamental plant Euphorbia milii Euphorbiaceae is plays a role in folk medicine The Chinese use it as a cure for cancer and some Brazilians believe that it can cure warts Phytochemical studies showed the presence of cardiac glycosides steroids phytosterols anthocyanin terpenoids flavonoids and tannins The Antimicrobial activity studies of hexane ethyl acetate chloform petroleum

  • Acute and Subchronic Toxicity Study of Euphorbia hirta L

    N nigricollis venom was administered intraperitoneally at a dose of 1414µg kg body weight of mice and Euphorbia hirta extract was orally administered at a dose of 250mg kg body weight at different time interval in the in vivo assay The result for the LD50 of the plant extract showed no mortality

  • In Vitro Anti‑inflammatory Activity of Fractionated

    Toxicity studies on the methanolic extract of Portulaca oleracea L were carried out on mice intraperitoneally The LD50 was calculated using the methods of Miller and Tainter LD50 1853 5 mg kg-1 Reed and Muench LD50 1871 mg kg-1 and Karber method LD50 1875 mg kg-1 these values placed the plant to be moderately toxic

  • Globinmed - Globinmed

    The Ethanolic Extract of Euphorbia hirta Linn showed positive test for flavonoids saponins glycosides tannins phenolics steroids proteins and carbohydrate The various doses of ethanolic extract of Euphorbia hirta Linn were shows no mortality in mice No toxic symptoms were observed even at the dose of 5000 mg kg The LD 50 value of

  • Antithrombotic and anti-inflammatory activities of leaf

    who used E hirta extract found the LD 50 to be over 5000 mg kg body weight consequently a dose of 200 400 and 800 mg kg day were therefore adopted for this study The animals were divided into five groups of 6 mice each and were orally administered with 200 400 and 800 mg kg day doses of the E hirta whole plant aqueous-methanolic

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